Another Evidence for God

Reading through Calvin's Institutes this year, and came across this:

"The miserable ruin, into which the rebellion of the first man cast us, especially compels us to look upward. Thus, not only will we, in fasting and hungering, seek thence what we lack; but, in being aroused by fear, we shall learn humility. or, as a veritable world of miseries is to be found in mankind, and we are thereby despoiled of divine raiment, our shameful nakedness exposes a teeming horde of infamies. Each of us must, then, be so stung by the consciousness of his own unhappiness as to attain at least some knowledge of God. "Thus, from the feeling of our own ignorance, vanity, poverty, infirmity, and-what is more-depravity and corruption, we recognize that the true light of wisdom, sound virtue, full abundance of every good, and purity of righteousness rest in the Lord alone."

Whenever lost man recognizes in himself some lack, some defect, is this not evidence of their innate knowledge of God -- of Romans 1 in action! Against whom (Whom!) are they making the comparison when they recognize the lack?